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antibiotic production and/or aerial mycelium formation in a variety of Streptomyces speciesl~~3\ Most of these factors which contain a y-butyrolactone ring have been discovered by intraspecific feeding experiments, in which an extract of the culture supernatant of one species stimulated antibiotic production and/or cellular differentiation of the same species. The regulatory mechanisms by which these

Wide Distribution of Interspecific Stimulatory Events on Antibiotic Production and Sporulation Among Streptomyces species.