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In the course of our screening for novel antibacterial antibiotics produced by microorganisms, a strain termed KSM-2690was found to produce a new complex of triene/3-lactone antibiotics in the culture filtrate. The active principle was recovered from the broth filtrate with ethyl acetate extraction and could be divided into six components, three major components KSM-2690 A (1), B (2) and C (3), and three minor components KSM-2690 D, E and F, on the basis of their respective order of elution under the reverse-phase HPLC. The characteristic UV and IR spectra of their components were similar to those of oxazolomycins1'2^ indicating that these new compoundsare members of the triene-/3-lactone group of antibiotics.

Novel Triene-.BETA.-lactone Antibiotics, Oxazolomycin Derivative and Its Isomer, Produced by Streptomyces sp. KSM-2690.