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Wehave isolated migrastatin (Fig. 1), as an inhibitor of tumor cell migration, from a cultured broth of Streptomyces sp. MK929-43F1. In the preceding paper1}, the taxonomy, fermentation, isolation and biological activities were reported. In this paper, we describe the physico-chemical properties and structure elucidation of migrastatin. Physico-chemical properties of migrastatin are summarized in Table 1. Migrastatin is readily soluble in methanol, acetone, ethyl acetate, chloroform and DMSO and practically insoluble in water and?z-hexane. Migrastatin was isolated as a white powderwith melting point of 54~55°C. The UV spectrum showed end absorption. Migrastatin gave positive color reaction with molybdophosphoric acid-sulfuric acid and 2,4-dinitrophenylhydrazine but negative with ninhydrin and Rydon-Smith. The molecular formula for migrastatin was established as C27H39NO7 by HRFAB-MS, which was supported by the *H and 13C NMRspectra. The DEPT and HMQCspectra exhibited 27 resonances; three methyl, one methoxy, seven methylene, five methine, one oxygen bearing methine, five olefinic methine, one quaternary olefinic and four carbonyl carbons. The !H NMRspectrum exhibited the presence of two deuterium exchangeable protons other than the protons which were attributed to the carbons described above. These !H and 13C chemical shifts are listed in Table 2.

Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. MK929-43F1.