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transduction from the microbial metabolites, because these inhibitors would be useful tool in elucidating the mechanismof GAsignal transduction. From the results of screening for the inhibitor of GAaction on the expression of a-amylase, Streptomyces sp. C39 was found to produce an active compound, gibbestatin B (1) and a new related compound, gibbestatin C (2). 1, renamed as gibbestatin B, has been reported as an antibiotic 2-ll-B from Streptomyces sp. 2-l l.4) However, the biological activities

journal of antibiotics

Isolation and Characterization of Gibbestatin B, an Inhibitor of Gibberellin-induced Expression of .ALPHA.-Amylase, and Gibbestatin C from Streptomycetaes.