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structures have been generated by mutasynthesis, directed fermentation, and enzymatic modification, and have been isolated from mutants and as minor components from the culture filtrate of the wild type strain. Here we report the isolation, structure elucidation, and antimicrobial activity of two novel nikkomycin derivatives, nikkomycins Lx and Lz, synthesized as main components by a genetically engineered mutant of S. tendae Tu901. The mutant was obtained by inserting a kanamycin resistance gene in the nikkomycin biosynthesis gene nikF encoding a cytochrome P450 monooxygenase (characterization and inactivation of the nikF gene will be separately published). To characterize the effect of the mutation on nikkomycin biosynthesis the nikF gene insertion mutant was cultivated in SP producpp. 582 585

Novel Nikkomycins Lx and Lz Produced by Genetically Engineered Streptomyces tendae Tue901.