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receptor is abundantly expressed in hypothalamus. Administration of recombinant leptin to objob (genetically obese and leptin deficient) or normal mice significantly suppresses food intake, body weight gain, and increase of energy expenditure3'43. These responses are accompanied by changes of several genes expression in the hypothalamus5'63. However the mechanisms by which leptin acts are still unknownand useful agonists/antagonists against leptin are not available. In the purpose of getting tools for understanding leptin's biological actions, low molecular weight microbial metabolites, which interact with leptin, were screened using a BIAcore instrument (BIAcore1.000, Biacore), the surface plasmon resonance sensor. The principle of the BIAcore system is that one molecule involved in the interaction to be studied is covalently immobilized to a sensor chip, and the other interactant (analyte) is then passed across the sensor chip. The detection system

Screening of Microbial Products Modifying the Action of Leptin (Obese Gene Product) by a Biosensor.