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A new antibiotic termed zelkovamycin was isolated from the fermentation broth of Streptomyces sp. K96-0670 by solvent extraction, ODS column chromatography and preparative HPLC. Zelkovamycin showed antibacterial activity against Xanthomonas oryzae, Acholeplasma laidlawii, Pyricularia oryzae and Staphylococcus aureus.

Zelkovamycin, a New Cyclic Peptide Antibiotic from Streptomyces sp. K96-0670. I. Production, Isolation and Biological Properties.