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In the course of our screening program for new antibacterial substances, an Actinoplanes strain A40665 isolated from a soil sample collected in Oita Prefecture, Japan, was found to produce an active compound. This compound, BE-40665D, was isolated from the mycelial cake of culture broth and the structure was elucidated as shown in Fig. 1. BE-40665D inhibited the growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). In this paper, the producing organism, fermentation, isolation, physicochemical properties, structure determination and biological properties of BE-40665D are described. Characterization of the producing strain followed the method adopted by the International Streptomyces Project (ISP)X) as well as several other tests. Strain A40665 had a deep orange vegetative mycelium and subglobose or irregular sporangia with a diameter of 6~ 10 x 10~ 12fim onthe surface of the agarmedia (Fig. 2). In contact with water, motile spores were released from the sporangia. The culture characteristics of strain A40665 are summarized in Table 1. Chemotaxonomic analysis of strain A40665 revealed meso-diaminopimelic

BE-40665D, a New Antibacterial Antibiotic Produced by an Actinoplanes sp.