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No. 2663. The taxonomy, fermentation, isolation and physico-chemical properties and biological activities have been described in the preceding papers1'2*. Herein we report on the structure elucidation of 1~3 (see Fig. 1) on the basis of spectroscopic and chemical evidence. Through the sequential purification of the ethyl acetate extract of fermentation broth was obtained FR901463 (1) as colorless needles (mp 102°C). Its IR spectrum and XH and 13C NMRspectra appear in the preceding paper1*. The molecular weight was indicated by FABMS (m/z 566 (M+Na)+). The M+Na+2 peak with approximately one-third intensity of the quasi molecular ion peak was characteristic of the presence of a chlorine atom. The molecular formula of C27H42C1NO8 was determined by interpretation of the 13C NMR(Table 2) and elemental analysis1*. The 13C spectrum exhibited 27 discrete carbon signals which were attributed to 6 CH3, 4 CH2, 12 CH including 5 sp2, 3 quaternary carbon including one sp2 and two carbonyl groups, indicating

New Antitumor Substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465.