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New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.

journal of antibiotics

Brasiliquinones A, B and C, New Benz(a)anthraquinone Antibiotics from Nocardia brasiliensis. I. Producing Strain, Isolation and Biological Activities of the Antibiotics.