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become new drugs for cancer treatment, not as biological response modifiers (BRM), but as anti-cancer chemicals exerting direct suppressive action on the growth or metastasis of certain cancers. Thus, the specific inhibition ofAP-N could be a new approach to suppress the growth or metastasis of cancer. During the screening for new inhibitors of aminopeptidase N, we obtained new substances MR-387Aand B (Fig. 1) from the culture broth of Streptomyces neyagawaensis SL-387. In this communication, we report 99

MR-387A and B, New Aminopeptidase N Inhibitors, Produced by Streptomyces neyagawaensis SL-387.