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Sparoxomycins A1 and A2, isolated from the fermentation broth and mycelium of Streptomyces sparsogenes SN2325, are new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. Sparoxomycins A1 and A2 were isolated by active carbon chromatography, centrifugal partition chromatography (CPC), ODS column chromatography and preparative HPLC. The structure of sparoxomycins were determined by spectroscopic evidences. Stereochemical assignments of these inducers were executed from the analyses of CD spectra.

journal of antibiotics

Sparoxomycins A1 and A2, New Inducers of the Flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus. II. Isolation, Physico-chemical Properties and Structure Elucidation.