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The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.

Chemistry of Pseudomonic Acid. Part 16. Aryl and Heteroaryl Ketone Derivatives of Monic Acid.