English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Yang Cai, Andreas Fredenhagen*, Paul HuGf and Heinrich H. Peter Core Drug Discovery Technologies, Pharmaceutical Research and t Research Services, Physics Department, CIBA-GEIGY Ltd., 4002 Basel, Switzerland (Received for publication April 1, 1996) Alkaloids of the indolocarbazole type bind to ATP-binding sites of various enzymes. Staurosporine isolated from Saccharothrix aerocolonigenes subsp. staurosporeusX) was found to be an inhibitor of protein kinase C (PKC) in the low nanomolar range2). Most other alkaloids of this type contain a six-membered sugar moiety like staurosporine3~6). A subgroup of these metabolites are K-252a (6)7) and K-252b8), which were isolated by Japanese researchers from two Nocardiopsis species strains as PKC inhibitors. In contrast to staurosporine these secondary metabolites have a fivememberedsugar moiety and a carboxylate function attached to this ring. Although a weaker inhibitor of PKCthan staurosporine, K-252b attracted considerable interest as it is able to potentiate neurotrophin-3 actions in vitro9). In previous publications we described several minor metabolites of Streptomyces longisporoflavus strain R-19 which were isolated as byproducts of a large scale staurosporine fermentation6' 1 0). In the present communication the structure elucidation, physicochemical data, and biological properties of further minor metabolites are described. Fermentation6) and isolation10) of the new compounds werereported earlier.

journal of antibiotics

The Shurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a.