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In our previous papers, wereported the structure and stereochemistry of thiomarinol A (previously referred to as thiomarinol)1'2*, produced by a marine bacterium, Alteromonas rava sp. nov. SANK733903), which has antimicrobial activity against Gram-positive and Gramnegative bacteria. Thiomarinol A (TMA) is a hybrid antibiotic composed of a pseudomonic acid analogue and holothin. In this paper we report the isolation, structure elucidation and antimicrobial activities of new thiomarinol derivatives, thiomarinols B (TMB)4) and C (TMC)5).

Thiomarinols B and C,New Antimicrobial Antibiotics Produced by a Marine Bacterium.