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poundswhich suppress function of mutated ras oncogene products have been screened for a use in treatment of these cancers1}. Inhibitors of ras farnesyltransferase has also been screened since farnesylation of ras proteins is needed for normal localization and function of ras proteins2). Biochemical and molecular analysis of ras proteins have revealed structural and functional similarity between human and yeast, Saccharomyces cerevisiae3\ According to amino acid sequence align-

Medelamines, Novel Anticancer Agents which Cancel RAS2val19 Induced Heat Shock Sensitivity of Yeast.