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screening for farnesyl-protein transferase (FPTase) inhibitors of microbial origin, we have discovered a novel compound: RPR113228 isolated from the fermentation broth of a fungus. We herein report the production, isolation, structure elucidation and inhibitory activities of this secondary metabolite. The producing strain was isolated from a soil sample. Aqueous soil suspension was spread on brain heart infusion agar supplemented with chloramphenicol and rose bengal (respectively, 0.2 and 0.05g/liter). It was

RPR113228, a Novel Farnesyl Protein Transferase Inhibitor Produced by Chrysosporium lobatum.