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Sir: Nagstatin (1) is a novel A^-acetyl-jft-D-glucosaminidase inhibitor isolated from culture nitrates of Streptomyces amakusaensis, and is structurally a nitrogenous 7V-acetylgalactosamine analog fused with an imidazole ring.1} Recently, we have synthesized de-branched nagstatin analogs having different configurations and functionalities, and then determined the absolute structure of nagstatin (1).2) Herein, we describe the syntheses and evaluation of the glycosidase inhibiting activities of analogs 2~6 as

Syntheses and Glycosidase Inhibiting Activities of Nagstatin Analogs.