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4'-Deoxy-10,11,12,13-tetrahydrodesmycosin was prepared in six-step reactions. Antibacterial screening shows retained antibacterial spectrum of tylosin with some improvement against tylosin-sensitive Staphylococci and Haemophilus influenze. However, the pharmacokinetic data demonstrated rapid distribution from blood in tissues and prolonged maintenance in all tissues, especially in the lungs, in comparison with tylosin.

journal of antibiotics

10,11,12,13-Tetrahydro Derivatives of Tylosin. II. Synthesis, Antibacterial Activity and Tissue Distribution of 4'-Deoxy-10,11,12,13-tetrahydrodesmycosin.