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Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly 1H NMR and 13C NMR. The substitution pattern was established by investigation of the respective methylated derivatives.

journal of antibiotics

Paeciloquinones A,B,C,D,E and F: New Potent Inhibitors of Protein Tyrosine Kinase Produced by Paecilomyces carneus. II. Characterization and Structure Determination.