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esperamicins Ax (esp Ax), Alb (esp Alb) and A2 (esp A2) have been reported1'3'40. The esperamicins consist of a bicyclic core to which attached a trisaccharide and a substituted 2-deoxy-L-fucose. The bicyclic core contains an enediyne, an allylic trisulfide and a bridgehead eneone. Esp AA (Fig. 1), the major component of the esperamicin family isolated from the fermentation of A. verrucosospora ATCC39334 grown in the complex mediumH9465), is one of the most potent antitumor agents yet discovered2). Three minor esperamicins, esp A2, esp Alb and esp P (Fig. 1) were also isolated from the large scale fermentation of A. verrucosospora ATCC 39334 grown in the complex medium5j6). While developing a defined medium for more efficient incorporation of labelled precursors into esp Ax during the biosynthetic studies7), we detected the formation of two new esperamicin analogs in a defined medium. We

Production and Isolation of Two Novel Esperamicins in a Chemically Defined Medium.