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The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25 approximately 12.5 micrograms/liter and 1.56 approximately 6.25 micrograms/ml against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and 12 strains of P. piscicida, respectively.

journal of antibiotics

Tetrodecamycin and Dihydrotetrodecamycin, New Antimicrobial Antibiotics against Pasteurella piscicida Produced by Streptomyces nashvillensis MJ885-mF8. I. Taxonomy, Fermentation, Isolation, Characterization and Biological Activities.