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Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.

journal of antibiotics

Crocacin, a new electron transport inhibitor from Chondromyces cracatus (myxobacteria). Production, isolation, physico-chemical and biological properties.