Open AccessBenastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.
Author(s) -
Takayuki Aoyama,
Fukiko Kojima,
Fuminori Abe,
Yasuhiko Muraoka,
Hiroshi Naganawa,
Tomio Takeuchi,
Takaaki Aoyagi
Publication year - 1993
Publication title -
pubmed
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.56
H-Index - 80
eISSN - 1881-1469
pISSN - 0021-8820
DOI - 10.7164/antibiotics.46.712
Subject(s) - glutathione , streptomyces , in vitro , glutathione s transferase , biology , biochemistry , isolation (microbiology) , chemistry , stereochemistry , microbiology and biotechnology , bacteria , enzyme , genetics
Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excellent stimulatory activities on the murine lymphocyte blastogenesis in vitro.