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Potent inhibitors of neuraminidase, 3, 4-didehydro-4-deoxysiastatin B, 4-deoxysiastatin B and N-[(S and R)-1, 2-dmydroxypropyl] derivatives of siastatin B, 3, 4-didehydro-4-deoxysiastatin B and 4-deoxysiastatin B have been synthesized by the chemical modifications of siastatin B.

Syntheses of the potent inhibitors of neuraminidase, N-(1,2-dihydroxypropyl) derivatives of siastatin B and ITS 4-deoxy analogs.