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Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.

journal of antibiotics

Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. 1. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.