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Herpesviruses are a commonvirus infecting man. Twodrugs have shown clinical efficacyin the treatment of herpesvirus infections, acyclovir and ganciclovir. Acyclovir has excellent antiviral activity against herpes simplex types 1 and 21}; ganciclovir is potent against human cytomegalovirus2). Both drugs are nucleoside analogs and are metabolized to their respective triphosphates which then block viral DNA replication by inhibiting the viral DNA polymerase3'4).

Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein.