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In a previous paper3), we reported on the synthesis and the biological activity of 3-methoxymethyl cephalosporin derivatives, one of which, cefpodoxime proxetil (Fig. 1), has been successfully developed as a prodrug for oral use. Our further elaboration for developing orally active cephalosporins has been made in the direction of chemical modification of the C-7 acyl substituent of the 3-methoxymethyl cephalosporin derivatives. 7-[2-(2-Aminooxazol-4-yl)-(Z)-2-alkoxyimino-

Synthesis and antibacterial activity of 7-(2-(2-aminooxazol-4-yl)-(z)-2-alkoxyiminoacetamido)-cephalosporin antibiotics.