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WS009 A and B, produced by Streptomyces sp. No. 89009, were found to be competitive and specific antagonists against endothelin (ET)-1 receptors in in vitro studies and also active in in vivo studies. Furthermore, WS009 A and B were specific antagonists for vascular ET-1 receptors (ETA receptors) and significantly prevented the accumulation of intracellular inositol 1,4,5-triphosphate (IP3) in endothelin treated rat aorta tissues.

journal of antibiotics

WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. No. 89009. II. Biological characterization and pharmacological characterization of WS009 A and B.