English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Interest in polyether antibiotics has remained at a high level for over 20 years, owing largely to the commercial importance of this class of drugs in veterinary medicine. For example, monensin1*, lasalocid1} and salmomycin2) are marketed as anticoccidial agents for poultry, and are used as growth permittants in cattle or swine. Narasin1} and maduramicin3) are also used as anticoccidial agents. Following the discovery of the attractive, semisynthetic anticoccidial ionophore semduramicin4'5) (UK-61,689), a mutation program was undertaken that was designed to produce this polyether antibiotic by direct fermentation6*. The producing culture of the antibiotic UK-58,852, was chosen as the parental strain to be mutagenically treated to induce a semduramicin producing mutant7'8). The two compounds differ from each other in that the A-ring glycone of UK-58,852 has been replaced by a hydroxyl group in semduramicin (Fig1).

CP-91,243 and CP-91,244, novel diglycoside polyether antibiotics related to UK-58,852 and produced by mutants of Actinomadura roseorufa.