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Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.

Synthesis and in vitro activity of new semisynthetic coumermycin analogs: Chemical modification at the C-3 amide.