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isolated from the culture broth of Streptomyces sandaensis No. 6897, was found to have unique structure1*^. FR-900482 differs from the mitomycin family of antibiotics due to the lack of a quinoid structure, although FR-900482 resembles the mitomycins with respect to the aziridine function and a carbamoyloxymethyl group. Examination of the structure suggests that the biosynthesis of FR-900482 may be presumed to be derived from a number of compoundswhich structurally resemble parts of the molecule. Recently, it has been reported that 3-amino5-hydroxybenzoic acid (AHBA) is involved in the biosynthesis of antibiotics, actamycin3), rifamycin B4), geldanamycin5) and mitomycins6). Theansamycinsand the mitomycinscontain a seven carbon amino unit, derived from AHBA. Furthermore, Hornemannand Aikman showed that in feeding D-[l-uC,15N]glucosamine to Streptomyces verticillatus, 14C was incorporated into mitomycin B and the 15N was incorporated into the aziridine ring to a similar extent and in

Precursors in the biosynthesis of FR-900482, a novel antitumor antibiotic produced by Streptomyces sandaensis.