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The novel chlorine-containing acidic polycyclic ether antibiotic CP-54,883 (C41H62O12Cl2) [corrected] is produced by the fermentation of Actinomadura routienii Huang sp. nov. This report presents the taxonomy and the fermentation conditions for the antibiotic-producing culture. The antibiotic is mainly active against Gram-positive bacteria. It protects chickens against Eimeria challenge in vivo and enhances rumen propionic acid in vitro. The physico-chemical properties are also characterized.

journal of antibiotics

CP-54,883 a novel chlorine-containing polyether antibiotic produced by a new species of Actinomadura: Taxonomy of the producing culture, fermentation, physico-chemical and biological properties of the antibiotic.