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A series of 3-methylthio-3-cephem-4-carboxylic acids were prepared to test their antibacterial activities, and 7-[R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido]-3-methylthio-3-ce phe m-4- carboxylic acid was found to be a new orally active antibiotic.

journal of antibiotics

Synthetic cephalosporins. II. The synthesis and oral activity of 7-(R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido)-3-methylthio-3-cephem-4-carboxylic acid and related compounds.