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ponents, mycotrienols I and II1). Independently, ZEECK et a!. isolated closely related compounds named ansatrienins A and B'), except for the stereochemistry of alanine. They also reported the isolation of two minor components, ansatrienins A2 and A3, wherein the cyclohexyl group of ansatrienin A is replaced by a 2-methylbutyryl group and an isovaleryl group, respectively'). Further screening for minor components of mycotrienins resulted in the isolation of two metabolites named 22-O-methylmycotrienin II and 19-deoxymycotrienin II. We wish to report the isolation and structural elucidation of these minor components in this article. The same fermentation procedure employed for mycotrienins" was repeated for the production of these two minor compounds. Consequently, a crude mixture of mycotrienins was obtained by extraction of the harvested mycelia with aqueous acetone and reextraction by ethyl acetate followed by evaporation to an oily syrup. Further purification of the minor components was performed by the method summarized in Fig. 2. The production yields of 22-O-methylmycotrienin II (3) and 19-deoxymycotrienin II (4) were 0.27 mg/liter and 0.5 mg/liter, respectively. 3; C37H32N208, SIMS, [MH]+ m/z 653, in beam EIMS [M-H,011 m/z observed 634.3664; calcd 634.3616, [a]D +373° (c 0.045, MeOH), UV 262 nm (s 44,100), 272 (57,600), and 281 (43,700), IR v KB 3400, 2930, 1720, 1685, 1675, 1650, 1615, 1250 cm-1, was obtained as a white powder which melted at 128°C. Fig. 1. Structures of mycotrienins.

Studies on mycotrienin antibiotics, a novel class of ansamycins. V. Isolation and structure determination of novel mycotrienin congeners.