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The synthesis and in vitro antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido] cephalosporins with various substituents at the 3-position in the cephem nucleus are described. Aminothiadiazolyl cephalosporins having pyridiniomethyl groups at the 3-position exhibited excellent activity against all organisms, particularly against Pseudomonas aeruginosa.

journal of antibiotics

Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.