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Various microorganisms were tested for capability to hydroxylate of ML-236B at the 3 beta-position. As the result, it was found that this ability was limited to a small group of microorganisms, mainly Zygomycetes in fungi, and Nocardia in actinomycetes.

Microbial hydroxylation of ML-236B (compactin) Studies on microorganisms capable of 3.BETA.-hydroxylation of ML-236B.