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A new polyene macrolide antifungal antibiotic, named tetrafungin, was isolated from the cultured mycelium of a Streptomyces strain. Fermentation, isolation, physico-chemical and biological properties of the antibiotic are described. Its UV absorption spectrum and its physico-chemical characteristics place this antibiotic in the group 2.2.2.3 of the Berdy classification.

Tetrafungin, a new polyene macrolide antibiotic. I. Fermentation, isolation, characterization, and biological properties.