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Auramycinone was subjected to microbial conversion by Streptomyces coeruleorubidus ATCC 31276, a producer of baumycins. As a result, auramycinone was converted to 11-hydroxyauramycinone and 9-methyl-10-hydroxydaunomycin (feudomycin D). The results implicate auramycinone as a presumptive intermediate in the biosynthesis of 9-methyl-10-hydroxydaunomycin by S. coeruleorubidus.

journal of antibiotics

Microbial conversion of anthracycline antibiotics II. Characterization of the microbial conversion products of auramycinone by Streptomyces coeruleorubidus ATCC 31276.