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25-Dihydrosaframycin A(AR1) and 21-decyano-25-dihydrosaframycin A(AR3) were produced by the microbial conversion of saframycin A(SA). Efficient conversion of SA to AR1 and AR3 was observed with Rhodococcus amidophilus IFM 144. Though the antimicrobial activity of AR1 was one tenth that of SA, the in vitro antitumor activity of AR1 was found to be equivalent to that of SA. In contrast, AR3 was biologically less active.

journal of antibiotics

Microbial conversion of saframycin A to 25-dihydrosaframycin A and 21-decyano-25-dihydrosaframycin A (25-dihydrosaframycin B) and their biological activities.