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Selective monoacylation of the antibiotic laidlomycin at C-26 has led to derivatives that display enhanced activity toward favorably altering rumen fermentation and preventing avian coccidiosis. Diacylated derivatives (C-7, C-26) were found to be inactive. The structures of these compounds were determined by 13C NMR spectroscopy.

Enhancement of the activity of the antibiotic laidlomycin by acylation and the 13C NMR spectra of laidlomycin and its esters.