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Miokamycin (MOM), a new macrolide antibiotic, was tested for mutagenicity in the Ames Salmonella test and the dominant lethal assay. MOM was not mutagenic against S. typhimurium strains TA1535-1538, TA100 and TA98 both with and without activation by S-9 mix. No increases in the frequencies of induced dominant lethal effects were found in MOM treated mice. MOM did not have mutagenic activities on either system.

Evaluation of the mutagenicity of miokamycin (MOM), a new macrolide antibiotic in the Ames Salmonella test and the dominant lethal assay.