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SF-1902 is a solvent-soluble, neutral antibiotic produced by Streptomyces hygroscopicus SF-19021). It shows antibacterial activity only against Gram-negative bacteria2). HPLC analysis of the sample seemingly homogeneous on TLC (silica gel, chloroform methanol, 5: 1, or acetone benzene, 2: 1) disclosed the presence of several minor components and one major component SF-1902, as shown in Fig. 1. Those were separated from each other by using a semipreparative LC column of pBondapak C18. Among these, SF-1902 and SF-1902 A5 were obtained as crystals. When 850 mg of the crude sample of SF-1902 was purified by recrystallization and semi-preparative LC, 530 mg of SF1902, 32 mg of A2, 100 mg of A3, 50 mg of A4 and 75 mg of A5 were obtained. SF-1902, a major component, was identified with globomycin3) by the direct comparison including ORD curves in chloroform. Among these minor components, only A5 was obtained as homogeneous crystals. Further purification and the structural studies of other minor components are now under study.

Isolation and structure of SF-1902 A5, a new globomycin analogue.