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C/s-dichlorodiammineplatinum (II) [cis-Pt (II) (NHs^Cy, and related compounds were first reported by Rosenberg et al.1-^ to have potent antitumor activities against sarcoma 180 and leukemia 1210 in mice. Subsequently, these compounds were reported effective against Dunning ascites leukemia and Walker 256 carcinosarcoma in rats3) and in other systems.4^6) Cis-Pt (II) (NH3)2C12 also causes inhibition of cell division and elongation of bacterial cells,7>8) prophage induction in bacteria,9) inhibition of DNA synthesis in mammalian cells,4) crosslinking of DNA in vivo10) and in vitro,n) and immunosuppression in mice.12>13) These ac-

A SIMILAR ACTION TO UV-IRRADIATION AND A PREFERENTIAL INHIBITION OF DNA SYNTHESIS IN E. COLI BY ANTITUMOR PLATINUM COMPOUNDS