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Sir: Studies by Rake et al.1^ showed mannosidostreptomycin to be less active and dihydrostreptomycin about equally active to streptomycin in inhibiting most Gram-negative and acid-fast bacteria. Davies et al.3) have reported that mannosidostreptomycin and dihydrostreptomycin were adenylated by enzymes from RTF-carrying strains of Escherichia coli, but did not indicate the Table 1. Substrate specificity of adenyl relative efficiencies of adenylation of these substrates. We have examined the adenylation of these 3 streptomycins by crude enzyme preparations (ammonium sulfate precipitated material) from several Gram-negative bacteria using techniques described by Yamada et al.v to study adenylation. As is shown in Table 1, mannosidostreptomycin is adenylated at between 10 and 20% of the rate of streptomycin and dihydrostreptomycin. If this is true for other Gram-negative streptomycin-resistant organisms, mannosidostreptomycin may be a more desirable antimicrobial agent than originally supposed9>2) in treating infections, especially those carrying RTF for streptomycin.

the journal of antibiotics

Identificação das principais manifestações patológicas em empreendimentos residenciais com base nos dados da assistência técnica de uma empresa construtora