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Seven derivatives of 6-chloro-2-quinoxalinecarboxylic acid 1, 4-dioxide were prepared. These include esters, amides and the acid hydrazide. The derivatives were tested against fifteen bacteria by agar diffusion assay and against two bacterial infections in vivo. Increased effectiveness on oral administration was observed with the carboxamide.

ANTIBIOTIC MSD-819. PREPARATION AND PROPERTIES OF BIOLOGICALLY ACTIVE DERIVATIVES