English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Adenosine A 1 receptors (A 1 ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, the role of A 1 ARs on ischemic damage and its subsequent neuroinflammatory response has been scarcely explored so far. Methods: In this study, the expression of A 1 ARs after transient middle cerebral artery occlusion (MCAO) was evaluated by positron emission tomography (PET) with [ 18 F]CPFPX and immunohistochemistry (IHC). In addition, the role of A 1 ARs on stroke inflammation using pharmacological modulation was assessed with magnetic resonance imaging (MRI), PET imaging with [ 18 F]DPA-714 (TSPO) and [ 18 F]FLT (cellular proliferation), as well as IHC and neurofunctional studies. Results: In the ischemic territory, [ 18 F]CPFPX signal and IHC showed the overexpression of A 1 ARs in microglia and infiltrated leukocytes after cerebral ischemia. Ischemic rats treated with the A 1 AR agonist ENBA showed a significant decrease in both [ 18 F]DPA-714 and [ 18 F]FLT signal intensities at day 7 after cerebral ischemia, a feature that was confirmed by IHC results. Besides, the activation of A 1 ARs promoted the reduction of the brain lesion, as measured with T 2 W-MRI, and the improvement of neurological outcome including motor, sensory and reflex responses. These results show for the first time the in vivo PET imaging of A 1 ARs expression after cerebral ischemia in rats and the application of [ 18 F]FLT to evaluate glial proliferation in response to treatment. Conclusion: Notably, these data provide evidence for A 1 ARs playing a key role in the control of both the activation of resident glia and the de novo proliferation of microglia and macrophages after experimental stroke in rats.

In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke

In vivo multimodal imaging of adenosine A₁ receptors in neuroinflammation after experimental stroke