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Multifunctional nanoplatforms with integrated diagnostic and therapeutic functions have attracted tremendous attention. Especially, the second near-infrared (NIR-II) light response-based nanoplatforms hold great potential in cancer theranostic applications, which is because the NIR-II window provides larger tissue penetration depth and higher maximum permissible exposure (MPE) than that of the well-studied first near-infrared (NIR-I) window. Herein, we for the first time present a two-dimensional (2D)-nanoplatform based on Cu 2 MnS 2 nanoplates (NPs) for magnetic resonance imaging (MRI)/multispectral optoacoustic tomography (MSOT) dual-modal imaging-guided photothermal therapy (PTT) of cancer in the NIR-II window. Methods: Cu 2 MnS 2 NPs were synthesized through a facile and environmentally friendly process. A series of experiments, including the characterization of Cu 2 MnS 2 NPs, the long-term toxicity of Cu 2 MnS 2 NPs in BALB/c nude mice, the applications of Cu 2 MnS 2 NPs for in vitro and in vivo MRI/MSOT dual-modal imaging and NIR-II PTT of cancer were carried out. Results: The as-synthesized Cu 2 MnS 2 NPs exhibit low cytotoxicity, excellent biocompatibility as well as high photothermal conversion efficiency (~49.38%) and outstanding photostability. Together with their good T  1 -shortening effect and strong absorbance in the NIR-I and NIR-II region, the Cu 2 MnS 2 NPs display high-contrast imaging performance both in MRI and MSOT (900 nm laser source). Moreover, the subsequent in vitro and in vivo results demonstrate that the Cu 2 MnS 2 NPs possess excellent PTT efficacy under 1064 nm laser irradiation with a low power density (0.6 W cm -2 ). In addition, the detailed long-term toxicity studies further confirming the safety of Cu 2 MnS 2 NPs in vivo . Conclusion: We have developed a new 2D Cu 2 MnS 2 NPs as multifunctional theranostic agents for MRI/MSOT dual-modal imaging-guided PTT of cancer in the NIR-II window. Such biocompatible Cu 2 MnS 2 NPs might provide a new perspective for exploring new 2D-based nanoplatforms with improved properties for clinical applications in the future.

theranostics

Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window