English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose : Long noncoding RNAs (lncRNAs) have been reported to be associated with the growth and progression of numerous cancers. The aim of this study was to explore the potential function and molecular mechanism of lncRNA ENST489676 in the proliferation and invasion of papillary thyroid cancer (PTC). Methods : QRT-PCR (quantitative reverse transcriptase-polymerase chain reaction) was used to determine the levels of ENST489676. CCK-8 (Cell Counting Kit-8) assay and colony formation assay were performed to detect the cell proliferation. Flow cytometry was used to analyze the cell cycle. Transwell and scratch assay were performed to detect the migration and invasion ability. Results : The expression of ENST489676 was significantly overexpressed in TPC1 compared to KTC1 cell lines. When ENST489676 expression was knocked down, the proliferation, migration and invasion ability as well as cell cycle were all promoted in PTC cell lines, while those abilities were all suppressed when ENST489676 overexpressed. Overexpression of ENST489676 could inhibit cell proliferation, migration and invasion in vitro. Moreover, ENST489676 may mediate tumor suppression in PTC cells through suppressing miR-922. Conclusions : ENST489676 negatively regulated the proliferation, migration invasion and cell cycle of PTC. The overexpression of ENST489676 inhibited the progression of PTC through suppressing miR-922. ENST489676 could be act as a novel diagnosis marker and a potential therapeutic target for PTC.

The Long Non-Coding RNA ENST00000489676 Influences Papillary Thyroid Cancer Cell Proliferation and Invasion through Regulating MiR-922