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The aim of the present study was to examine the conditions and chemicals that affect the expression of circadian clock-related genes in obesity. We investigated the expression of Per1 mRNA in H35 cultured rat hepatoma cells. Incubation with 100 nM dexamethasone for 2 h increased Per1 mRNA expression successfully in H35 rat hepatoma cells after 19 h or 22 h of stimulation. Further, 50 mM oleic acid (OA) loading resulted in marked accumulation of triglycerides in H35 cells and decreased the elevated levels of dexamethasone-induced Per1 mRNA after 19 h or 22 h of stimulation. Resveratrol and niacin did not show any effect on Per1 mRNA expression in H35 cells. However, eicosapentaenoic acid (EPA) reversed the OA-induced reduction in Per1 mRNA after dexamethasone stimulation in the cultured cells. These data suggest the possible role of EPA as an agent to modify the circadian clock oscillation.

Eicosapentaenoic Acid Reverses the Oleic Acid-induced Reduction in Per1 mRNA Expression in Cultured Rat Hepatocytes